Implementation of inclisiran in United Kingdom primary care for patients with atherosclerotic cardiovascular disease or its-risk equivalents: rationale and design of Victorion-spirit, a pragmatic phase IIIb, randomised controlled study
| العنوان: | Implementation of inclisiran in United Kingdom primary care for patients with atherosclerotic cardiovascular disease or its-risk equivalents: rationale and design of Victorion-spirit, a pragmatic phase IIIb, randomised controlled study |
|---|---|
| المؤلفون: | Paul M. Wilson, Samantha Dixon, Tracey Vell, Peter Bower, Linda Rootkin, Claire Williams, Adam Strong, David Lawrence, Rebecca Elvey, Owen Williams, Norman Stein, J. Martin Gibson |
| المصدر: | International Journal of Clinical Trials. 10:156-165 |
| بيانات النشر: | Medip Academy, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Ocean Engineering |
| الوصف: | Background: Translational gaps exist in implementing health innovations rapidly in clinical practice. Pragmatic effectiveness and implementation studies, therefore, play a pivotal role in understanding how high-value health innovations could be deployed and delivered in healthcare systems to reduce barriers to adoption and provide more rapid patient benefit. Victorion-spirit is an ongoing pragmatic, 9-month, phase IIIb, open-label, multicentre, randomised controlled study evaluating the implementation, patient experience, and delivery of the subcutaneous lipid-lowering therapy, inclisiran sodium 300 mg, in participants with elevated low-density lipoprotein cholesterol (LDL-C) who are on established lipid-lowering medication, or have been recommended lipid-lowering therapy, but are unable to tolerate treatment. Methods: Victorion-spirit utilises a type 1 hybrid effectiveness-implementation design, where the primary objective is to demonstrate superiority of inclisiran with or without (±) behavioural support versus standard of care (SOC; e.g., statin and/or other lipid-lowering therapies) + behavioural support in terms of percentage reduction in LDL-C from baseline to Day 270 in a primary care setting. Secondary objectives will evaluate implementation of inclisiran ± behavioural support versus SOC + behavioural support through assessment of patient satisfaction and patient activation/empowerment after treatment at Day 90; adherence to cardiovascular disease self-management; and serious adverse event profile. Additionally, a process evaluation ascertaining the views of patients, providers and national health service (NHS) commissioners will explore barriers and enablers to integrating inclisiran within primary care. Conclusions: The results of Victorion-spirit have potential to change our approach to lipid management and inform further implementation efforts in healthcare systems, such as the NHS. Trial registration: ClinicalTrials.gov NCT04087400. |
| تدمد: | 2349-3259 2349-3240 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0a18899662bda4ba8ef8c3159562d063 https://doi.org/10.18203/2349-3259.ijct20231106 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........0a18899662bda4ba8ef8c3159562d063 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23493259 23493240 |
|---|