Anti-plasmodial, Anti-inflammatory, anti-nociceptive and safety profile of Maytenus senegalensis root bark extract on hepato-renal integrity in experimental animals
| العنوان: | Anti-plasmodial, Anti-inflammatory, anti-nociceptive and safety profile of Maytenus senegalensis root bark extract on hepato-renal integrity in experimental animals |
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| المؤلفون: | Muhammad Ndako, Gabriel Femi Ibikunle, Sheriff Itopa Umar, Ali Audu Jigam, Sherifat Funmilola Adefolalu, Bashir Lawal |
| المصدر: | Comparative Clinical Pathology. 28:1571-1579 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Aspirin, Kidney, Traditional medicine, medicine.drug_class, business.industry, medicine.medical_treatment, Analgesic, Parasitemia, medicine.disease, Anti-inflammatory, Pathology and Forensic Medicine, medicine.anatomical_structure, Chloroquine, medicine, Anatomy, Hot plate test, business, Saline, medicine.drug |
| الوصف: | Maytenus senegalensis is a plant with several medicinal claims in folk medicine. Methanol root extract of the plant was evaluated for antiplasmodial, anti-inflammatory, anti-nociceptive, and safety profile. Antiplasmodial, anti-inflammatory (egg albumin induced paw edema), and analgesic (hot plate test) experiments were set up, each consisting of four (4) groups (A-D) of five mice each. Groups A–C of each experiment were treated with 2.0 ml/kg bw normal saline, 400 and 800 mg/kg bw of the extract according to the procedures. Chloroquine, acetyl salicylic, and aspirin respectively were used as the reference drugs. Hematological and biochemical parameters were evaluated after 4-week administration of the extract to four groups of five rats each at oral daily doses of 0, 200, 400, and 800 mg/kg bw, respectively. At 400 and 800 mg/kg bw, the extract caused 58.88% and 58.49% inhibition of parasitemia, and 51.92% and 54.66% inhibition of paw edema, respectively. The reaction time to the thermal stimuli increased (p 0.05) with their reference values. The extract alters some functional integrity of kidney, and thus caution should be exercised when using the extract for the above pharmacological activities or other oral remedy. |
| تدمد: | 1618-565X 1618-5641 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0aec98d2e6f4cc8aa32aac327ce708f9 https://doi.org/10.1007/s00580-019-02965-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........0aec98d2e6f4cc8aa32aac327ce708f9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1618565X 16185641 |
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