Interpretations. Cardiovascular disease and combined oral contraceptives: reviewing the evidence and balancing the risks
| العنوان: | Interpretations. Cardiovascular disease and combined oral contraceptives: reviewing the evidence and balancing the risks |
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| المؤلفون: | Timothy M.M. Farley, O. Meirik, John A. Collins |
| المصدر: | Human Reproduction Update. 5:721-735 |
| بيانات النشر: | Oxford University Press (OUP), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Gynecology, medicine.medical_specialty, business.industry, Public health, Obstetrics and Gynecology, Context (language use), Gestodene, Reproductive Medicine, Desogestrel, Family planning, Epidemiology, medicine, Levonorgestrel, business, Developed country, Demography, medicine.drug |
| الوصف: | Cardiovascular risks have been a concern since combined oral contraceptives (OCs) were first introduced. In the past four years new, mostly reassuring information on the safety of modern, low oestrogen dose OCs has become available. However, in 1995 the new information showed higher venous thromboembolism (VTE) risk for OCs containing desogestrel and gestodene compared with levonorgestrel- or norethindrone-containing OCs. The controversial responses by national authorities, their scientific and public health merits were hotly debated and many considered the differences in risk small and resulted from bias and/or confounding. We discuss these arguments and conclude they lack empirical support or cannot account for the 2-fold increased risk. The risk of ischaemic stroke and myocardial infarction (MI) associated with low oestrogen dose OCs are very small in women without cardiovascular risk factors, while increased risk of haemorrhagic stroke is confined to women >35 years of age. Applying the most recent risks to models of OC-attributable events and deaths, OC-attributable mortality in women |
| تدمد: | 1460-2369 1355-4786 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0b4407e14e515a8e787ae5b18fdd265e https://doi.org/10.1093/humupd/5.6.721 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........0b4407e14e515a8e787ae5b18fdd265e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602369 13554786 |
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