Metabolome plasticity in 241 Arabidopsis thaliana accessions reveals evolutionary cold adaptation processes
| العنوان: | Metabolome plasticity in 241 Arabidopsis thaliana accessions reveals evolutionary cold adaptation processes |
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| المؤلفون: | Jakob Weiszmann, Dirk Walther, Pieter Clauw, Georg Back, Joanna Gunis, Ilka Reichardt, Stefanie Koemeda, Jakub Jez, Magnus Nordborg, Jana Schwarzerova, Iro Pierides, Thomas Nägele, Wolfram Weckwerth |
| المصدر: | Plant Physiology. |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology, Genetics, Plant Science |
| الوصف: | Acclimation and adaptation of metabolism to a changing environment are key processes for plant survival and reproductive success. In the present study, 241 natural accessions of Arabidopsis (Arabidopsis thaliana) were grown under two different temperature regimes, 16 °C and 6 °C, and growth parameters were recorded, together with metabolite profiles, to investigate the natural genome × environment effects on metabolome variation. The plasticity of metabolism, which was captured by metabolic distance measures, varied considerably between accessions. Both relative growth rates and metabolic distances were predictable by the underlying natural genetic variation of accessions. Applying machine learning methods, climatic variables of the original growth habitats were tested for their predictive power of natural metabolic variation among accessions. We found specifically habitat temperature during the first quarter of the year to be the best predictor of the plasticity of primary metabolism, indicating habitat temperature as the causal driver of evolutionary cold adaptation processes. Analyses of epigenome- and genome-wide associations revealed accession-specific differential DNA-methylation levels as potentially linked to the metabolome and identified FUMARASE2 as strongly associated with cold adaptation in Arabidopsis accessions. These findings were supported by calculations of the biochemical Jacobian matrix based on variance and covariance of metabolomics data, which revealed that growth under low temperatures most substantially affects the accession-specific plasticity of fumarate and sugar metabolism. Our findings indicate that the plasticity of metabolic regulation is predictable from the genome and epigenome and driven evolutionarily by Arabidopsis growth habitats. |
| تدمد: | 1532-2548 0032-0889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0b51e3ec020d665c2ffa3155a5bc7615 https://doi.org/10.1093/plphys/kiad298 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........0b51e3ec020d665c2ffa3155a5bc7615 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322548 00320889 |
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