ASSESSMENT OF ANXIOLYTIC POTENTIAL OF NEW С2,С3- QUINOXALINE DERIVATIVES
| العنوان: | ASSESSMENT OF ANXIOLYTIC POTENTIAL OF NEW С2,С3- QUINOXALINE DERIVATIVES |
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| المؤلفون: | Dmitry V. Maltsev, Alexander A. Spasov, Maria O. Skripka, Mikhail V. Miroshnikov, Lyudmila N. Divaeva, Anatoly S. Morkovnik, Alexander A. Zubenko, Alexander I. Klimenko |
| المصدر: | Journal of Volgograd State Medical University. 19:135-142 |
| بيانات النشر: | Volgograd State Medical University, 2022. |
| سنة النشر: | 2022 |
| الوصف: | The anxiolytic effect of a new series of C2,C3-quinoxaline derivatives was studied using the "Anxious-phobic state" and "Light/Dark chamber" techniques in comparison with diazepam. It was noted that the presence of a phenyl substituent at the C3 position, which did not contain elements with a distinct electronegativity, as well as 2-methyl-(4,5-dimethoxyphenyl)-N-methylethane-1-amine at the C2 position, had a positive effect on the manifestation of the antianxiety activity of new derivatives of C2,C3-quinoxaline. For the most active compound under the code ZDM-4, the conflict method "Vogel Conflict test" was additionally carried out to confirm the anxiolytic effect of the substance. The tranquiLizing potential of the ZDM-4 compound is of interest for further study. |
| تدمد: | 1994-9499 1994-9480 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0bc7478375d323fcec7cdfb8cfd39ec4 https://doi.org/10.19163/1994-9480-2022-19-2-135-142 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........0bc7478375d323fcec7cdfb8cfd39ec4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19949499 19949480 |
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