Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome
| العنوان: | Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome |
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| المؤلفون: | Abdelahhad Barbour, Leif Smith, Morvarid Oveisi, McKinley Williams, Ruo Chen Huang, Cara Marks, Noah Fine, Chunxiang Sun, Fereshteh Younesi, Sina Zargaran, Ravi Orugunty, Thomas D. Horvath, Sigmund J. Haidacher, Anthony M. Haag, Amarpreet Sabharwal, Boris Hinz, Michael Glogauer |
| المصدر: | Proceedings of the National Academy of Sciences. 120 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Lantibiotics are ribosomally synthesized and posttranslationally modified peptides (RiPPs) that are produced by bacteria. Interest in this group of natural products is increasing rapidly as alternatives to conventional antibiotics. Some human microbiome–derived commensals produce lantibiotics to impair pathogens’ colonization and promote healthy microbiomes. Streptococcus salivarius is one of the first commensal microbes to colonize the human oral cavity and gastrointestinal tract, and its biosynthesis of RiPPs, called salivaricins, has been shown to inhibit the growth of oral pathogens. Herein, we report on a phosphorylated class of three related RiPPs, collectively referred to as salivaricin 10, that exhibit proimmune activity and targeted antimicrobial properties against known oral pathogens and multispecies biofilms. Strikingly, the immunomodulatory activities observed include upregulation of neutrophil-mediated phagocytosis, promotion of antiinflammatory M2 macrophage polarization, and stimulation of neutrophil chemotaxis—these activities have been attributed to the phosphorylation site identified on the N-terminal region of the peptides. Salivaricin 10 peptides were determined to be produced by S. salivarius strains found in healthy human subjects, and their dual bactericidal/antibiofilm and immunoregulatory activity may provide new means to effectively target infectious pathogens while maintaining important oral microbiota. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0cec476ec0b260d00b55a1b2db10e39a https://doi.org/10.1073/pnas.2219392120 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........0cec476ec0b260d00b55a1b2db10e39a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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