Amyotrophic Lateral Sclerosis (ALS) is a progressive neurological disease that leads to degeneration of motor neurons and, as a result, inhibits the ability of the brain to control muscle movements. Monitoring the progression of ALS is of fundamental importance due to the wide variability in disease outlook that exists across patients. This progression is typically tracked using the ALS functional rating scale - revised (ALSFRS-R), which is the current clinical assessment of a patient’s level of functional impairment including speech and other motor tasks. In this paper, we investigated automatic estimation of the ALSFRS-R bulbar subscore from acoustic and articulatory movement samples. Experimental results demonstrated the AFSFRS-R bulbar subscore can be predicted from speech samples, which has clinical implication for automatic monitoring of the disease progression of ALS using speech information.
