Continuous Process Improvement in the Manufacture of Carfilzomib, Part 1: Process Understanding and Improvements in the Commercial Route to Prepare the Epoxyketone Warhead
| العنوان: | Continuous Process Improvement in the Manufacture of Carfilzomib, Part 1: Process Understanding and Improvements in the Commercial Route to Prepare the Epoxyketone Warhead |
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| المؤلفون: | Guilong Charles Cheng, Neil F. Langille, Alicia Zeng, Jenil Patel, Chris Scardino, Travis Anthoine, William E. Lake, Scott W. Roberts, Matthew G. Beaver, John L. Tucker, Shawn D. Walker, Dawn E. Cohen, William Powazinik, Peter K. Dornan, Sheng Cui, Simone Spada, Susan P. Lucas |
| المصدر: | Organic Process Research & Development. 24:481-489 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Computer science, Process (engineering), business.industry, Process development, Organic Chemistry, Process improvement, Carfilzomib, chemistry.chemical_compound, chemistry, Warhead, Proteasome inhibitor, medicine, Physical and Theoretical Chemistry, Process engineering, business, medicine.drug |
| الوصف: | Epoxyketone 4 is an isolated intermediate in the manufacturing route to the commercial proteasome inhibitor carfilzomib (Kyprolis). Commercial process development and optimization efforts toward th... |
| تدمد: | 1520-586X 1083-6160 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0d83d0a8ad40e0186b29fa7df348a5b2 https://doi.org/10.1021/acs.oprd.0c00051 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........0d83d0a8ad40e0186b29fa7df348a5b2 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1520586X 10836160 |
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