Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe
| العنوان: | Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe |
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| المؤلفون: | Yiqing Zhou, Jingyuan Xu, Xin Chen, Shi Yue, Youli Xiao, Xu Yue, Zhangshuang Deng, Suyun Zhong, Nai-Kei Wong |
| المصدر: | Analytical Chemistry. 92:4419-4426 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_classification, In situ, biology, Chemistry, Drug discovery, 010401 analytical chemistry, Endogeny, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Fatty acid synthase, chemistry.chemical_compound, Enzyme, Biochemistry, Biosynthesis, Cancer cell, biology.protein, Molecular imaging |
| الوصف: | Cancer cells rely on fatty acid synthase (FASN), a key enzyme for de novo biosynthesis of long chain fatty acids, to sustain their proliferative potential and drive invasion. Unfortunately, conventional FASN assays are technically inadequate for discerning otherwise elusive FASN activity in complex biological milieux, which has hindered progress in the functional study of FASN and development of its inhibitors. Here, we describe a chemical probe with unprecedented selectivity and sensitivity for the labeling of active FASN in living cells, thus demonstrating a new analytical modality for visualizing endogenous FASN activity and exploring opportunities for drug discovery. |
| تدمد: | 1520-6882 0003-2700 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0fb4e4938dc815ac39db88ae895bcfe2 https://doi.org/10.1021/acs.analchem.9b05327 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........0fb4e4938dc815ac39db88ae895bcfe2 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206882 00032700 |
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