Action of dipyridamole on megakaryocytopoiesis in regenerating and static bone marrow cell populations
| العنوان: | Action of dipyridamole on megakaryocytopoiesis in regenerating and static bone marrow cell populations |
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| المؤلفون: | Almazov Va, Ivasenko In, Bliudzin IuA, Cherniakova Dn, G. E. Arkad'eva |
| المصدر: | Bulletin of Experimental Biology and Medicine. 114:1813-1816 |
| بيانات النشر: | Springer Science and Business Media LLC, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pathology, education.field_of_study, Chemistry, Population, General Medicine, General Biochemistry, Genetics and Molecular Biology, Dipyridamole, Endocrinology, medicine.anatomical_structure, Cytoplasm, Docosahexaenoic acid, Internal medicine, medicine, Distribution (pharmacology), Bone marrow, education, Bone marrow cell, Megakaryocytopoiesis, medicine.drug |
| الوصف: | The effect of dipyridamole on megakaryocytopoiesis in regenerating and stationary populations of mouse bone marrow cells has been studied by heterotopic transplantation of the bone marrow using histological, electron microscopic and biochemical techniques. It is shown that drug administration induced destruction of megakaryocytes. In megakaryocytic cytoplasm giant lipid granules were found whose growth and number increase resulted in megakaryocytes kill. Gas-liquid chromatography was used to evaluate the effect of dipyridamole on distribution of lipid fatty acids of the stationary and regenerating populations of the bone marrow cells. A marked increase of the percentage of docosahexaenoic acid was found in lipids of the stationary population. Chronic dipyridamole administration caused an increase of percentage of myristic, palmitic oleic acids, and decrease of percentage of arachidonic and eicosapentaenoic acids in lipids of regenerating bone marrow cells population. |
| تدمد: | 1573-8221 0007-4888 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0febc2fb3634b6814d9c0a57edd33fae https://doi.org/10.1007/bf00840469 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........0febc2fb3634b6814d9c0a57edd33fae |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15738221 00074888 |
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