التفاصيل البيبلوغرافية
| العنوان: |
Hypomethylating Agent 5-Aza-2′-deoxycytidine (DAC) Ameliorates Multiple Sclerosis in Mouse Models |
| المؤلفون: |
Katia Mangano, Lucia Malaguarnera, Ferdinando Nicoletti, Santa Mammana, Pier Luigi Meroni, Gaetano Magro, Michelino Di Rosa, Paolo Fagone, Cinzia Quattrocchi, Marinella Coco, Roberto Di Marco, Klaus Bendtzen |
| المصدر: |
Journal of Cellular Physiology. 229:1918-1925 |
| بيانات النشر: |
Wiley, 2014. |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
Physiology, business.industry, Encephalomyelitis, Multiple sclerosis, Clinical Biochemistry, Cell, FOXP3, Context (language use), Cell Biology, medicine.disease, chemistry.chemical_compound, medicine.anatomical_structure, Hypomethylating agent, chemistry, Immunology, Medicine, Deoxycytidine, Epigenetics, business |
| الوصف: |
Increasing evidence supports the role of epigenetics in the development of autoimmune disorders and the possibility of using epigenetic modifying drugs in the context of MS has not yet been investigated. We have explored the effect of the hypomethylating agent 5-aza-2′-deoxycytidine (DAC) in two murine models of experimental allergic encephalomyelitis (EAE). DAC treatment was associated with a significant amelioration of the clinical and histological hallmarks of EAE in both models. These effects were observed both in prophylactic and therapeutic regimens. The milder course of the disease was associated with a reduction in the number of spinal cord infiltrating lymphocytes and amelioration of the histopathological signs associated with EAE. In addition, increased transcript levels of anti-inflammatory cytokines and decreased mRNA expression of pro-inflammatory mediators were also observed. Finally, DAC treatment increased the percentage of circulating regulatory T cells by inducing Foxp3 expression via demethylation of a CpG island in Foxp3. J. Cell. Physiol. 229: 1918–1925, 2014. © 2014 Wiley Periodicals, Inc. |
| تدمد: |
0021-9541 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::10c84b518ae1578d4f69ff8488e57877
https://doi.org/10.1002/jcp.24641 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.doi...........10c84b518ae1578d4f69ff8488e57877 |
| قاعدة البيانات: |
OpenAIRE |
