Dynamics of the vitamin D C3-epimer levels in preterm infants
| العنوان: | Dynamics of the vitamin D C3-epimer levels in preterm infants |
|---|---|
| المؤلفون: | Tomas Matejek, Bara Zapletalova, Martin Stepan, Jana Malakova, Vladimir Palicka |
| المصدر: | Clinical Chemistry and Laboratory Medicine (CCLM). 61:1084-1094 |
| بيانات النشر: | Walter de Gruyter GmbH, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry (medical), Clinical Biochemistry, General Medicine |
| الوصف: | Objectives The primary objective was to determine levels of C3-epi-25(OH)D in very low birth weight infants. The secondary objective was to evaluate the possible influence of preterm birth, intrauterine growth restriction (IUGR), and season of birth on the production of C3-epimers. Methods A total of 127 infants with birth weight less than 1,500 g met the inclusion criteria of the study. We examined 25-hydroxyvitamin-D [25(OH)D] levels and C3-epi-25(OH)D in maternal serum before labor, and in cord blood and infants’ serum on days 14 and 28, and at discharge. Results The mean levels (±SD) of C3-epi-25(OH)D of the cord, on day 14, on day 28, and at discharge were 2.2 (2.9), 7.7 (5.5), 11.7 (7.6) and 14.9 (11.7) nmol/L respectively. The proportion of total 25(OH)D as the C3-epimer was 6.9% (cord), 16.3% (day 14), 22.4% (day 28) and 23.3% (discharge). A statistically significant correlation between 25(OH)D and C3-epi-25(OH)D can be demonstrated from birth. The severity of immaturity and IUGR did not affect the production of C3-epimers. In summer/autumn vs. winter/spring, the mean (SD) percentage of total 25(OH)D as the C3-epimer significantly differs only in maternal serum samples and umbilical cord samples (p value Conclusions The production of C3-epi-25(OH)D is functional even in the most immature newborns, has fetal origins, and is largely dependent on circulating 25(OH)D. At the end of the first month of life, C3-epimers make up more than 20% of 25(OH)D. |
| تدمد: | 1437-4331 1434-6621 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::137926c5aff22ae9bfdfedc43ab747b1 https://doi.org/10.1515/cclm-2022-1128 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........137926c5aff22ae9bfdfedc43ab747b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
|---|