Individual risk prediction of high grade prostate cancer based on the combination between total prostate-specific antigen (PSA) and free to total PSA ratio
| العنوان: | Individual risk prediction of high grade prostate cancer based on the combination between total prostate-specific antigen (PSA) and free to total PSA ratio |
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| المؤلفون: | Simona Ferraro, Davide Biganzoli, Roberta Simona Rossi, Franco Palmisano, Marco Bussetti, Enrica Verzotti, Andrea Gregori, Filippo Bianchi, Marco Maggioni, Ferruccio Ceriotti, Cristina Cereda, Gianvincenzo Zuccotti, Peter Kavsak, Mario Plebani, Giuseppe Marano, Elia Mario Biganzoli |
| المصدر: | Clinical Chemistry and Laboratory Medicine (CCLM). 61:1327-1334 |
| بيانات النشر: | Walter de Gruyter GmbH, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry (medical), Clinical Biochemistry, General Medicine |
| الوصف: | Objectives Clinical practice guidelines endorse the stratification of prostate cancer (PCa) risk according to individual total prostate-specific antigen (tPSA) values and age to enhance the individual risk-benefit ratio. We defined two nomograms to predict the individual risk of high and low grade PCa by combining the assay of tPSA and %free/tPSA (%f/tPSA) in patients with a pre-biopsy tPSA between 2 and 10 μg/L. Methods The study cohort consisted of 662 patients that had fPSA, tPSA, and a biopsy performed (41.3% with a final diagnosis of PCa). Logistic regression including age, tPSA and %f/tPSA was used to model the probability of having high or low grade cancer by defining 3 outcome levels: no PCa, low grade (International Society of Urological Pathology grade, ISUP Results The nomogram identifying patients with: (a) high vs. those with low grade PCa and without the disease showed a good discriminating capability (∼80%), but the calibration showed a risk of underestimation for predictive probabilities >30% (a considerable critical threshold of risk), (b) ISUP50%. In ISUP 5 a possible loss of PSA immunoreactivity has been observed. Conclusions The estimated risk of high or low grade PCa by the nomograms may be of aid in the decision-making process, in particular in the case of critical comorbidities and when the digital rectal examinations are inconclusive. The improved characterization of the risk of ISUP≥3 might enhance the use for magnetic resonance imaging in this setting. |
| تدمد: | 1437-4331 1434-6621 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::140d8f668f4452f1accbe99729cbd0e2 https://doi.org/10.1515/cclm-2023-0008 |
| رقم الأكسشن: | edsair.doi...........140d8f668f4452f1accbe99729cbd0e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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