Relationship of severe dysplasia to Stage B adenocarcinoma of the prostate
| العنوان: | Relationship of severe dysplasia to Stage B adenocarcinoma of the prostate |
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| المؤلفون: | Brian D. Quinn, Kathleen R. Cho, Jonathan I. Epstein |
| المصدر: | Cancer. 65:2328-2337 |
| بيانات النشر: | Wiley, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Prostatectomy, business.industry, musculoskeletal, neural, and ocular physiology, medicine.medical_treatment, Histology, Nodule (medicine), macromolecular substances, medicine.disease, medicine.anatomical_structure, nervous system, Oncology, Dysplasia, Prostate, medicine, Carcinoma, Adenocarcinoma, Stage (cooking), medicine.symptom, business |
| الوصف: | Severe dysplasia was studied in totally embedded radical prostatectomy specimens from 40 Stage B, intermediate-grade prostate cancers. All 40 cases had severe dysplasia which varied in amount (extensive in 35% of cases; intermediate in 55%; minimal in 10%). Severe dysplasia was predominantly concentrated in peripheral and posterior regions of the gland. Those cases with extensive severe dysplasia had more multifocal small cancers (14.6/case) compared with cases with intermediate (7.5/case) or minimal severe dysplasia (5.5/case). Most dominant tumor nodules had some intermingled severe dysplasia, and in 30% of the dominant tumor nodules, intermingled severe dysplasia occupied between 10% and 25% of the tumor nodule. Severe dysplasia was located next to the dominant tumor nodule in all cases. Nineteen percent of dominant tumor nodules had extensive adjacent severe dysplasia ranging from 5 to 14 mm in maximum diameter, showing that the potential exists for needle biopsy of prostate cancers to obtain only severe dysplasia. These data show a close relationship between severe dysplasia and Stage B cancers. In contrast, centrally located low-grade multifocal cancers, as seen in Stage A (incidental) carcinoma, had a significantly weaker association with severe dysplasia as compared with central, intermediate-grade, multifocal tumors or peripheral multifocal tumors of any grade. |
| تدمد: | 1097-0142 0008-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1451e76ada302e7eaea0b0fcc0265d90 https://doi.org/10.1002/1097-0142(19900515)65:10<2328::aid-cncr2820651027>3.0.co;2-o |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........1451e76ada302e7eaea0b0fcc0265d90 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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