Background: In this study we are going to discuss the relationship between blood pressure level and serum uric acid level in chronic hemodialysis patients.Aim of the Work: Evaluation of the relation between blood pressure level and serum uric acid level in chronic hemodialysis patients.Subjects and Methods: The cross-sectional study was conducted at Tanta university Hospital from January 2016 to June 2016, and comprised 200 CKD patients on regular hemodialysis. Blood pressure was measured just before and after dialysis and every one hour during dialysis in 3 consec-utive sessions. Uric acid levels were measured just before and after hemodialysis.Results: Of the 200 patients, odds ratio for high uric acid level in the group with predialysis systolic hypertension was 0.363 (95% CI: 0.148–0.893; p=0.027), for predialysis diastolic hypertension was 0.652 (95% CI: 0.192–1.523; p=0.126) and 0.528 (95% CI: 0.357–1.754; p=0.213) for intradialysis hy-potension.Conclusion: This study showed paradoxical association between high uric acid level and high systolic blood pressure.