Infectious agents and immune responses in schizophrenia: A case control study
| العنوان: | Infectious agents and immune responses in schizophrenia: A case control study |
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| المؤلفون: | Mohammed Imad Al-Deen Mustafa Mahmud, Berjees Rafi, Umeed Ali Khan, Hassan Mohamed El Hady |
| المصدر: | IIUM Medical Journal Malaysia. 15 |
| بيانات النشر: | IIUM Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Immune system, business.industry, Schizophrenia (object-oriented programming), Immunology, Case-control study, Medicine, General Medicine, business |
| الوصف: | Introduction: Exact causal mechanism of schizophrenia is still unknown; however, genetic and environmental factors are implicated in disease aetiology. The aim of the study is to determine the association of infectious agents cytomegalovirus and T.gondii along with immune cytokines IL-2, IL-6 and IFN-γ with schizophrenia. Methods: Ninety subjects participated in the study, 45 were patients diagnosed with schizophrenia, and the other 45 were a healthy control group. Qualitative and quantitative enzyme immunoassays were used for detection of antibodies and quantitation of cytokines respectively in subjects’ sera. Results: Both patients and control groups had similar CMV seroprevalence of 93.3% (42/45). Prevalence of anti T. gondii IgG antibodies were 53.3% and 64.4% among schizophrenic patients and controls respectively. No statistically significant difference was observed between patients and controls (p > 0.05). A significant difference (p0.05) was found between the median IQR serum Interleukin-6 levels of patients (4.3 pg/mL) and controls (3.1 pg/mL). There was a significant difference (p< 0.001) in median IQR serum IFN – γ levels between patients (0.8 pg/mL) and the control group (4.9 pg/mL). Conclusions: No significant differences between schizophrenic patients and healthy controls with regard to previous infections with cytomegalovirus or T.gondii were observed. While significantly higher levels of proinflammatory cytokines IL-6 and IFN – γ among controls than patients might be an indication of weaker than normal immune responses in schizophrenic patients. |
| تدمد: | 2735-2285 1823-4631 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::164d6429c1773ba38d259724f02c7500 https://doi.org/10.31436/imjm.v15i1.1374 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........164d6429c1773ba38d259724f02c7500 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 27352285 18234631 |
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