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'Physiologische' und 'neoplastische' C-Zell-Hyperplasien der Schilddrüse

التفاصيل البيبلوغرافية
العنوان: 'Physiologische' und 'neoplastische' C-Zell-Hyperplasien der Schilddrüse
المؤلفون: Ulrich Schneyer, Michael Brauckhoff, Raoul Hinze, Oliver Gimm, Henning Dralle, Hans-Jürgen Holzhausen
المصدر: Der Pathologe. 22:259-265
بيانات النشر: Springer Science and Business Media LLC, 2001.
سنة النشر: 2001
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Thyroid, Hyperplasia, Biology, medicine.disease, Pathology and Forensic Medicine, Neoplastic C-Cell Hyperplasia, Thyroid carcinoma, medicine.anatomical_structure, Proto-Oncogene Proteins c-ret, medicine, Mutation testing, Multiple endocrine neoplasia
الوصف: C-cell hyperplasia (CCH) occurs regularly in the setting of type 2 multiple endocrine neoplasia (MEN2), either separately or in association with medullary thyroid carcinoma (MTC). It can also accompany sporadic MTC and appear without any tumour association. To test the practicability of the terms "physiologic" and "neoplastic", 18 cases with incidental sporadic, non-MTC associated CCH were investigated and the morphological patterns were described. We found CCH of various degrees, including so-called neoplastic CCH. In 16 of the 18 cases, a MEN2 setting could be ruled out by mutation analysis of the RET proto-oncogene. Morphologically, one can not distinguish with certainty between sporadic and hereditary or reactive and tumour-associated CCH. While MEN2-associated CCH can be regarded as true preneoplasia, sporadic CCH possesses variable biologic potential. The preneoplastic potential of sporadic CCH is still obscure. A pure morphological distinction between "physiologic" and "neoplastic" CCH regardless of the RET status should not be used.
تدمد: 1432-1963
0172-8113
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::173f330743996cdec076969b3bf1fee2
https://doi.org/10.1007/s002920100468
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........173f330743996cdec076969b3bf1fee2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14321963
01728113