Amyotrophic lateral sclerosis phenotypes significantly differ in terms of magnetic susceptibility properties of the precentral cortex
| العنوان: | Amyotrophic lateral sclerosis phenotypes significantly differ in terms of magnetic susceptibility properties of the precentral cortex |
|---|---|
| المؤلفون: | Fabio Triulzi, Giorgio Conte, Claudia Cinnante, Vincenzo Silani, Elisa Scola, Sara Sbaraini, Luca Caschera, Francesco Maria Lo Russo, Silvia Casale, Claudia Morelli, Silvia Siggillino, Francesca Trogu, Valeria Elisa Contarino |
| المصدر: | European Radiology. 31:5272-5280 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, medicine.diagnostic_test, Upper motor neuron, business.industry, Quantitative susceptibility mapping, Magnetic resonance imaging, General Medicine, medicine.disease, Lower motor neuron, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cortex (anatomy), medicine, Radiology, Nuclear Medicine and imaging, Radiology, Amyotrophic lateral sclerosis, business, Neuroradiology, Motor cortex |
| الوصف: | The aim of our study was to investigate whether the magnetic susceptibility varies according to the amyotrophic lateral sclerosis (ALS) phenotypes based on the predominance of upper motor neuron (UMN)/lower motor neuron (LMN) impairment. We retrospectively collected imaging and clinical data of 47 ALS patients (12 with UMN predominance (UMN-ALS), 16 with LMN predominance (LMN-ALS), and 19 with no clinically defined predominance (Np-ALS)). We further enrolled 23 healthy controls (HC) and 15 ALS mimics (ALS-Mim). These participants underwent brain 3-T magnetic resonance imaging (3-T MRI) with T1-weighted and gradient-echo multi-echo sequences. Automatic segmentation and quantitative susceptibility mapping (QSM) were performed. The skewness of the susceptibility values in the precentral cortex (SuscSKEW) was automatically computed, compared among the groups, and correlated to the clinical variables. The Kruskal-Wallis test showed significant differences in terms of SuscSKEW among groups (χ2(3) = 24.2, p < 0.001), and pairwise tests showed that SuscSKEW was higher in UMN-ALS compared to those in LMN-ALS (p < 0.001), HC (p < 0.001), Np-ALS (p = 0.012), and ALS-Mim (p < 0.001). SuscSKEW was highly correlated with the Penn UMN score (Spearman’s rho 0.612, p < 0.001). This study demonstrates that the clinical ALS phenotypes based on UMN/LMN sign predominance significantly differ in terms of magnetic susceptibility properties of the precentral cortex. Combined MRI-histopathology investigations are strongly encouraged to confirm whether this evidence is due to iron overload in UMN-ALS, unlike in LMN-ALS. • Magnetic susceptibility in the precentral cortex reflects the prevalence of UMN/LMN impairment in the clinical ALS phenotypes. • The degree of UMN/LMN impairment might be well described by the automatically derived measure of SuscSKEW in the precentral cortex. • Increased SuscSKEW in the precentral cortex is more relevant in UMN-ALS patients compared to those in Np-ALS and LMN-ALS patients. |
| تدمد: | 1432-1084 0938-7994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::17c30f8d40da0ecb2578e72c6cf39d88 https://doi.org/10.1007/s00330-020-07547-5 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........17c30f8d40da0ecb2578e72c6cf39d88 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321084 09387994 |
|---|