Diabetic patients are prone to develop wounds in the lower limbs. The predisposing factors include neuropathy, which is a common chronic complication of persistent hyperglycemia, affecting the autonomic nervous system render their skin dry, with a loss of the accommodating sweating reflex, furthermore, the sensory loss for touch and minor injuries let them a prey for repetitive injuries without adopting protective measures. The microvascular and macrovascular complications ultimately result in hemodynamics disturbances and peripheral ischemia. Immunological responses are dampened by diabetes, further enhancing the chance for deteriorating and delaying the healing of the wounds.
