Hizikia fusiforme extract enhances dendritic cell maturation in vitro and in vivo
| العنوان: | Hizikia fusiforme extract enhances dendritic cell maturation in vitro and in vivo |
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| المؤلفون: | Jun Hwi Cho, Mi Eun Kim, Hyung Keun Kim, Inae Jung, Jun Sik Lee |
| المصدر: | Bioscience, Biotechnology, and Biochemistry. 84:1861-1869 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Chemistry, Organic Chemistry, Priming (immunology), hemic and immune systems, chemical and pharmacologic phenomena, General Medicine, Dendritic cell, Hizikia fusiforme, Applied Microbiology and Biotechnology, Biochemistry, In vitro, Analytical Chemistry, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Immune system, Antigen, In vivo, Molecular Biology, 030215 immunology, Biotechnology |
| الوصف: | Dendritic cells (DCs) are play critical roles in the priming and regulation of immune responses. DCs rapidly process and convey these antigens to prime antigen-specific T cells. Therefore, regulation of DCs functions is important for immunity and immunotherapies. Immune adjuvants for DCs activation are needed to improve the efficacy of vaccines against tumors and many infectious diseases. Therefore, we demonstrate that H. fusiformis extract can regulate DCs maturation and activation. H. fusiformis extract induced costimulatory molecules (CD 80 and CD86), antigen-presenting molecules (major histocompatibility complex (MHC) I and II), CCR7 expression, and interleukin (IL)-12 production in DCs. These effects are associated with upregulation of mitogen-activated protein kinase (MAPK) signaling pathway. In addition, H. fusiformis extract induces costimulatory molecules on splenic DCs and activated CD8+ T cells in vivo. Taken together, these findings suggest that H. fusiformis extract may be a potential efficient immune therapeutic compound in DCs-mediated immunotherapies. Abbreviations CTL: cytotoxic T lymphocytes; DCs: dendritic cells; ERK: extracellular signal-regulated kinases; IL: interleukini; JNK: c-Jun N-terminal kinase; MAPK: mitogen-activated protein kinase; MHC: major histocompatibility complex |
| تدمد: | 1347-6947 0916-8451 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::19051aa5b7b0058af72c02d883afe8d0 https://doi.org/10.1080/09168451.2020.1772037 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........19051aa5b7b0058af72c02d883afe8d0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 13476947 09168451 |
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