Every job demands human resources to improve the quality of their work. The importance of work productivity for nurses is an evaluation material to make continuous improvements for all hospital components, improving the quality of work results by hospitals. According to Kepmenkes No. 129 of 2008 regarding hospital minimum service standards, in the inpatient unit, patient satisfaction with an indicator of 90% while at Pekanbaru Medical Center Hospital the level of patient satisfaction is 77.5%. This study aims to determine the factors related to the work productivity of nurses in the inpatient ward of Pekanbaru Medical Center Hospital in 2022. This type of research is quantitative with a cross sectional design. The population is all nurses in the inpatient room totaling 65 people with a total sample of the entire population. The sampling technique used is total sampling. Data analysis was carried out univariate and bivariate with chi square test (α = 0.05). Bivariate results showed a significant relationship between motivation (P = 0.000 < = 0.05), work discipline (P = 0.000 < = 0.05), income level (P = 0.000 < = 0.05), and work environment with work productivity. So the conclusions and suggestions for the Pekanbaru Medical Center Hospital are to increase the work productivity of nurses in providing health care services to the community and as an evaluation material to increase the work productivity of nurses.