Prognostic value of longitudinal assessment of inflammatory and nutritional status in patients undergoing valvular heart surgery
| العنوان: | Prognostic value of longitudinal assessment of inflammatory and nutritional status in patients undergoing valvular heart surgery |
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| المؤلفون: | D Hung, Y K Tse, Q W Ren, J Y Huang, K H Yiu |
| المصدر: | European Heart Journal. 44 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Background Novel strategies to improve the long-term risk stratification of valvular surgery are urgently needed as a result of the increasing prevalence of valvular heart diseases globally. Purpose This study aimed to evaluate the prognostic implications of longitudinal assessment of inflammatory and nutritional status in patients undergoing valvular surgery. Methods 1046 patients who underwent valvular surgery were stratified into three groups based on their inflammatory (neutrophil-to-lymphocyte ratio [NLR]) and nutritional status (prognostic nutritional index [PNI]): without inflammation and malnutrition (normal), inflammation or malnutrition alone (mild), and concomitant inflammation and malnutrition (severe). Optimal NLR and PNI thresholds for predicting all-cause mortality were determined using receiver-operating characteristic analysis. The endpoints were all-cause mortality, cardiovascular death and adverse events (composite of death and heart failure [HF] hospitalization). Results Over a median follow-up of 4.3 years (IQR: 2.6 to 6.4 years), 139 (13.3%) deaths and 148 (14.1%) HF hospitalizations occurred. Based on the optimal cut-off of NLR >4.06 (inflammation) and PNI Conclusion Concomitant inflammation and malnutrition is common and is strongly associated with mortality and HF in patients undergoing valvular surgery. Beyond conventional risk scores, assessments of inflammatory and nutritional status using NLR and PNI before and after surgery may provide additional prognostic value for long-term outcomes following valvular surgery. |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1d17dfc7889ca7fe8128c376d1a0fa20 https://doi.org/10.1093/eurheartj/ehac779.098 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........1d17dfc7889ca7fe8128c376d1a0fa20 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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