Chemistry of Phosphonium Ylides. Part 39: Facile Synthesis of Aziridine, Pyridine, Pyrolotriazole Chromenones and Azaphosphinin Chromenones as Antitumor Agents
التفاصيل البيبلوغرافية
العنوان:
Chemistry of Phosphonium Ylides. Part 39: Facile Synthesis of Aziridine, Pyridine, Pyrolotriazole Chromenones and Azaphosphinin Chromenones as Antitumor Agents
The reaction of 4-azido-2-oxo-2H-chromene-3-carbaldehyde with the active nucleophilic phosphacumulenes yielded the corresponding phosphanylidene-aziridines and chromeno-pyrolo-triazoles. On the other hand, the reaction of the allylic phosphonium ylide, hexaphenylcarbodiphosphorane with the azido compound, was also undertaken. In this case, the phosphanylidene-chromeno-triazinone was obtained. Further assessment of these new compounds against (breast: MCF-7 and liver: HPEG2) human solid tumor cell lines is necessary.
