Endometriosis: Insulin-like growth factor binding proteins in peritoneal fluid of women with minimal and mild endometriosis
| العنوان: | Endometriosis: Insulin-like growth factor binding proteins in peritoneal fluid of women with minimal and mild endometriosis |
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| المؤلفون: | Ronald D. Wiehle, Randall C. Dunn, Rakesh Mangal, Omur Taskin, Linda C. Giudice, B A Dsupin, Alfred N. Poindexter |
| المصدر: | Human Reproduction. 11:1741-1746 |
| بيانات النشر: | Oxford University Press (OUP), 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Infertility, medicine.medical_specialty, biology, business.industry, Peritoneal fluid, Rehabilitation, Endometriosis, Proteolytic enzymes, Obstetrics and Gynecology, Radioimmunoassay, Luteal phase, medicine.disease, Insulin-like growth factor-binding protein, Endocrinology, Reproductive Medicine, Internal medicine, Follicular phase, medicine, biology.protein, business |
| الوصف: | This prospective cohort study was carried out in a university-based infertility clinic to determine the profile of insulin-like growth factor binding proteins (IGFBPs) in patients with mild endometriosis and no obvious mechanical factor contributing to infertility. A total of 26 patients with minimal and mild endometriosis and 10 controls contributed peritoneal fluid at surgery. The variety, expression and levels of IGFBPs were determined by radioimmunoassay and Western ligand blots (WLBs) with quantitation by laser densitometer. A 27 kDa species was significantly lower and a 31 kDa species tended to be lower in patients with endometriosis as determined by quantitative laser densitometer. The levels of IGFBP-3 detected by radioimmunoassay and by WLB were correlated in the control group and in the patients with endometriosis in the follicular phase but not in patients with endometriosis in the luteal phase. The level of 27 kDa species seen on WLBs did not appear to correspond to IGFBP-1 determined by radioimmunoassay and IGFBP-3 levels in luteal phase endometriosis patients also departed from values determined by radioimmunoassay. These discrepancies suggest a complex system to control levels of IGF in the peritoneum involving multiple binding proteins and proteases. The IGFBPs of patients with endometriosis may contribute to reproductive dysfunction and be able to serve as markers. |
| تدمد: | 1460-2350 0268-1161 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1e32ef5f450e6ec926e8d940294f5df3 https://doi.org/10.1093/oxfordjournals.humrep.a019479 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........1e32ef5f450e6ec926e8d940294f5df3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602350 02681161 |
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