Screening Assessment of Renal Function Status in Healthy Smoking Volunteers
| العنوان: | Screening Assessment of Renal Function Status in Healthy Smoking Volunteers |
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| المؤلفون: | Vadim A. Salomatin, Irina V. Sidorova, Ildaria Valeeva, Julia Vladimirovna Oslopova, Evgeniya V. Gnuchikh, Dilyara D. Safina, Sayar Abdulkhakov, Evgeniya E. Arinina, Alina A. Ibragimova, Evgenii V. Arkhipov, Rashat I. Faizullin, Ekaterina Ju. Pronina, A. Kiassov, Leila R. Gaysina |
| المصدر: | BioNanoScience. 9:510-514 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Kidney, medicine.diagnostic_test, business.industry, medicine.medical_treatment, 030232 urology & nephrology, Biomedical Engineering, Renal function, Bioengineering, Physical examination, Urine, urologic and male genital diseases, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Blood pressure, Renal pathology, Internal medicine, medicine, Albuminuria, Smoking cessation, 030212 general & internal medicine, medicine.symptom, business |
| الوصف: | The study objective was to evaluate the renal function status in overall healthy smokers. Renal function status was studied in 61 apparently healthy smokers aged 21–64 years (49 males and 12 females). The evaluation included taking a history with the smoking status assessment, a physical examination with assessment of systolic and diastolic blood pressure, blood and urine biochemistry, and calculation of glomerular filtration rate (GFR; CKD-EPI, 2009). The period of observation lasted for 7 days. High blood pressure and obesity had no impact on the kidney function (p > 0.05). Healthy smoking volunteers initially had a high GFR and a “high-normal” urine albumin level as compared to the group of healthy non-smokers (р = 0.000 and р = 0.012, respectively). The risk analysis showed that smoking increased 11-fold the risk of hyperfiltration (RR = 11.1, CI 95% 1.57–76.51, p = 0.001) and 5-fold the occurrence of albuminuria (RR = 5.1, CI 95% 0.71–36.99, p = 0.009) in smokers without initial renal pathology as compared to never-smokers. Those who abstained from smoking showed a moderate decrease of albuminuria (p = 0.049). Systematic tobacco consumption contributes to the development of a renal dysfunction with the occurrence of albuminuria and hyperfiltration (GFR ≥ 125 ml/min/1.73 m2). Timely smoking cessation promotes the regression of albuminuria. |
| تدمد: | 2191-1649 2191-1630 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::21f8e5bc3514b8f7fc375b1d48dceea4 https://doi.org/10.1007/s12668-019-0602-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........21f8e5bc3514b8f7fc375b1d48dceea4 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 21911649 21911630 |
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