Association Study of Single-Nucleotide Polymorphisms on Chromosome 1p13, 1p32, 9p21 and 19p13 with Cardiovascular Diseases in Chinese Han Population: A Case-Control Study
التفاصيل البيبلوغرافية
العنوان:
Association Study of Single-Nucleotide Polymorphisms on Chromosome 1p13, 1p32, 9p21 and 19p13 with Cardiovascular Diseases in Chinese Han Population: A Case-Control Study
Objectives: Previous research discovered single nucleotide polymorphism (rs2383206 and rs2383207) on chromosome 9p21 that is associated with coronary heart disease in a Chinese population. However, few data are available on the association of other single nucleotide polymorphism with cardiovascular disease in a Chinese population. This study aimed to determine whether the single nucleotide polymorphisms on chromosome 1p13, 1p32, 9p21 and 19p13 were associated with coronary artery disease in a Chinese population. Methods: We conducted a case-control study. Cases were coronary artery disease (n=670) between 2010 and 2015. Controls (n=1340) were randomly selected and frequency matched to cases on age and gender. All of the participants were selected to study 18 single nucleotides using allele-specific real-time polymerase chain reaction method. Results: Four single nucleotides in 9p21, two single nucleotides in 1p13 and one single nucleotide in 1p32 were associated with cardiovascular disease risk in Chinese population (Global P value for multiple logistic regression
