Plasma Isolation in a Syringe by Conformal Integration of Inertial Microfluidics
| العنوان: | Plasma Isolation in a Syringe by Conformal Integration of Inertial Microfluidics |
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| المؤلفون: | Don L. DeVoe, Jung Yeon Han |
| المصدر: | Annals of Biomedical Engineering. 49:139-148 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Plunger, Microchannel, Materials science, Instrumentation, 0206 medical engineering, Microfluidics, Biomedical Engineering, Mechanical engineering, 02 engineering and technology, Plasma, 020601 biomedical engineering, Flow focusing, Spiral (railway), Syringe |
| الوصف: | A thermoplastic microfluidic substrate is conformally integrated onto the cylindrical barrel of a conventional venipuncture syringe, forming a spiral inertial separation element supporting the isolation of plasma from diluted whole blood. The cylindrical shape of the syringe itself serves to define the flow path required for inertial separation by transforming a linear microchannel to a spiral topology. The hybrid system enables inertial plasma separation by Dean flow focusing within the same syringe used for a patient blood draw, with the seamlessly interconnected microfluidic element operated by automated or manual actuation of the syringe plunger. Plasma isolation is achieved without the need for external instrumentation. Device design and fabrication challenges are discussed, and effective plasma isolation within the system is demonstrated, with a peak separation efficiency above 97% using 25 × diluted blood. |
| تدمد: | 1573-9686 0090-6964 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::238c88b039bf41251f21c1a8bfa3da2d https://doi.org/10.1007/s10439-020-02526-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........238c88b039bf41251f21c1a8bfa3da2d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15739686 00906964 |
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