The antiiflammatory effect of Ginkgo biloba in lipopolysaccharide-induced rat sepsis model
| العنوان: | The antiiflammatory effect of Ginkgo biloba in lipopolysaccharide-induced rat sepsis model |
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| المؤلفون: | Nevin Ilhan, Burcu Gül Baykalir, Solmaz Susam, Tuba Parlak Ak |
| المصدر: | LaboratoriumsMedizin. 42:45-49 |
| بيانات النشر: | Walter de Gruyter GmbH, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Flunixin, Lipopolysaccharide, biology, Ginkgo biloba, business.industry, Biochemistry (medical), Clinical Biochemistry, 030208 emergency & critical care medicine, Pharmacology, biology.organism_classification, medicine.disease, Sepsis, 03 medical and health sciences, Medical Laboratory Technology, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, medicine, business, medicine.drug |
| الوصف: | Background:Sepsis is characterized dysregulated inflammatory response and is the leading cause of organ failure or injury and death in critical care units.Ginkgo bilobaextract 761 (EGb 761) is characterized by antioxidant activity. There is no clear data in the functional role of EGb 761 that inhibiting of proinflammatory cytokines exist in sepsis. The purpose of this study was to investigate the antiinflammatory effect of EGb 761 on the levels of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS) induced rat sepsis model.Methods:The animals were randomly divided into the following six groups: the control, LPS, flunixin meglumine (FM), EGb 761, LPS+FM and LPS+EGb 761 groups. Enzyme-linked immunosorbent assay (ELISA) analysis was applied to measure serum levels of VEGF, MMP-9, and iNOS.Results:Serum iNOs (pConclusions:It is suggested that sepsis may lead to increase serum iNOs, MMP-9, and VEGF levels and treatment of EGb 761 may have a potential antiinflammatory effect against LPS-induced sepsis. |
| تدمد: | 1439-0477 0342-3026 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::23f004ffa0bc83aed9dbe0af6b06d0c6 https://doi.org/10.1515/labmed-2017-0113 |
| رقم الأكسشن: | edsair.doi...........23f004ffa0bc83aed9dbe0af6b06d0c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390477 03423026 |
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