We address the evolution of the shelf architecture of the Northeast Brazilian Equatorial Margin during the Plio-Pleistocene, using a coupled approach of sequence stratigraphy based on 3D seismic data, and cyclostratigraphy based on well-log data. The main purpose of this study is to highlight the major forcing processes that control evolution and architecture of the shelf during the Plio-Pleistocene.Our results reveal nine pronounced seismic sequences within the Plio-Pleistocene series, which are correlated to the long 405-kyr eccentricity cycles. Inside the two youngest 405-kyr cycles, we observe nine Falling Stage System Tracts (FSST) matching the short (97-128 kyr) eccentricity cycles. Finally, we identify three major depositional episodes (mega-sequences) in the Plio-Pleistocene: (i) the first episode (from ~4 to ~2.4 Ma) is characterized by small amplitudes of sea-level variations with low to none erosive structures and the absence of clear transgressive series, (ii) the second phase (from ~2.4 to ~0.9 Ma) records a drastic increase of erosional features as well as the apparition of thicker transgressive series and slope failures, and (iii) the third phase (from ~0.9 to present-day) is characterized by a dramatic change in the shelf geometry, most of the sediments are deposited on the slope during FSST while the outer shelf is greatly exposed and eroded during low sea levels. Our results suggest that long-term increase in amplitude of sea level variation is the main driver of the geometrical changes of the Brazilian shelf. Boundaries of mega-sequences at 0.9 and 2.4 Ma likely reflect major climatic phases at respectively the Intensification of Northern Hemisphere Glaciation and the Mid-Pleistocene Transition. A significant change in the shelf architecture at around 0.4 Ma, acting as a prominent shift in the depositional system from one prograding to another aggrading, is likely related to the substantial sea-level rise together with the long-lasting Marine Isotopic Stage 11. We conclude that changes in the Brazilian shelf geometry during the Plio-Pleistocene was likely paced by orbitally forced sea-level cycles superimposed on long-term trends and phases in the climate and sea level.