817 Robotic Semi-Automated Transcranial Doppler Assessment of Cerebrovascular Autoregulation in Post Concussional Syndrome: Methodological Considerations
| العنوان: | 817 Robotic Semi-Automated Transcranial Doppler Assessment of Cerebrovascular Autoregulation in Post Concussional Syndrome: Methodological Considerations |
|---|---|
| المؤلفون: | Fahim Anwar, Adel Helmy, Piotr Smielewski, Marek Czosnyka, D Z Khan, Karol P. Budohoski, Michał M. Placek, Manohar Bance, Peter J. Hutchinson |
| المصدر: | British Journal of Surgery. 108 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physical medicine and rehabilitation, business.industry, Cerebrovascular autoregulation, Medicine, Surgery, business, Transcranial Doppler |
| الوصف: | Introduction Post-concussive syndrome (PCS) refers to a constellation of physical, cognitive, and emotional symptoms after traumatic brain injury (TBI). Despite its incidence, the underlying mechanisms are unclear. We hypothesised that impaired cerebral autoregulation (CA) is a contributor. Method A prospective, observational study was integrated into outpatient clinics at a tertiary neurosurgical centre. Data points included: demographics, symptoms (Post-Concussion Symptom Scale [PCSS]), neuropsychological assessment (Cambridge Neuropsychological Test Automated-Battery [CANTAB]) and cerebrovascular metrics (Mxa co-efficient and the transient hyperaemic-response ratio [THRR]) - via transcranial Doppler (TCD), plethysmography and bespoke software (ICM+). Results 12 participants were recruited with 2 excluded after unsuccessful cerebrovascular TCD insonation. 10 participants (5 TBI patients, 5 healthy controls) were included in the analysis (median age 26.5, male:female 7:3). Median PCSS scores were 6/126 (TBI subgroup). Median CANTAB percentiles were 78 (healthy controls) and 25 (TBI). Mxa was calculated for 90% and THRR for 50% of participants. Median study time was 127.5 minutes and feedback (n = 6) highlighted the perceived acceptability of the study. Conclusions This pilot study has demonstrated a feasible and reproducible assessment of PCS and CA metrics (non-invasively) in a real-world setting. By scaling this methodology, we hope to test whether CA changes are correlated with symptomatic PCS in patients post-TBI. |
| تدمد: | 1365-2168 0007-1323 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::25d0e87d9099eb6578b2395e163e20b5 https://doi.org/10.1093/bjs/znab135.003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........25d0e87d9099eb6578b2395e163e20b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652168 00071323 |
|---|