Tumor Expression ofmiR-10b, miR-21, miR-143andmiR-145Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population
| العنوان: | Tumor Expression ofmiR-10b, miR-21, miR-143andmiR-145Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population |
|---|---|
| المؤلفون: | William C. Cho, Ondrej Slaby, Martina Redova-Lojova, Milana Šachlová, Marek Svoboda, Peter Grell, Petra Vychytilova-Faltejskova, Rostislav Vyzula, Radka Obermannova |
| المصدر: | Anticancer Research. 38:3719-3724 |
| بيانات النشر: | Anticancer Research USA Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, business.industry, Advanced stage, Cancer, General Medicine, European population, medicine.disease, Tumor tissue, law.invention, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, law, 030220 oncology & carcinogenesis, Internal medicine, microRNA, medicine, Clinicopathological features, In patient, business, Polymerase chain reaction |
| الوصف: | Background/aim In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and methods Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143, and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results Expression levels of miR-10b, miR-21, miR-93, and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population. |
| تدمد: | 1791-7530 0250-7005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::26de5bdcb19e7f887888e7424fb15331 https://doi.org/10.21873/anticanres.12651 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........26de5bdcb19e7f887888e7424fb15331 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
|---|