Background: Although postoperative nausea and vomiting (PONV) commonly occurs after spinal anesthesia, it has been scarcely studied. Therefore, we aimed to investigate its incidence rate and potential predictors.Methods: The electronic medical records of 6,610 consecutive patients undergoing orthopedic surgery under spinal anesthesia between January 2016 and December 2020 were reviewed. The primary outcome was PONV incidence within 24 h after spinal anesthesia. Along with its incidence rate, we investigated its predictors using multivariable logistic regression analysis. We also performed an interaction analysis for the primary outcome between the baseline PONV risk (low to medium vs. high) and the number of prophylactic agent.Results: Among the 5,691 patients included in the analysis, 1,298 (22.8%) experienced PONV within 24 h after spinal anesthesia. Female sex (odds ratio [OR]=3.18; 95% confidence interval [CI], 2.67–3.78; P3R antagonist (OR=0.35; 95% CI, 0.24–0.50; PConclusions: Our study showed the common incidence of PONV after spinal anesthesia and its significant predictors. A better understanding of its predictor may provide important information for its management.
