Influence of endothelial glycocalyx layer microstructure upon its role as a mechanotransducer
| العنوان: | Influence of endothelial glycocalyx layer microstructure upon its role as a mechanotransducer |
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| المؤلفون: | Vinod Suresh, Richard Clarke, Tet Chuan Lee |
| المصدر: | Journal of Fluid Mechanics. 893 |
| بيانات النشر: | Cambridge University Press (CUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0303 health sciences, animal structures, Chemistry, Mechanical Engineering, fungi, Poromechanics, Theoretical models, Condensed Matter Physics, Endothelial glycocalyx, Microstructure, 01 natural sciences, 010305 fluids & plasmas, 03 medical and health sciences, Biological literature, Mechanics of Materials, embryonic structures, 0103 physical sciences, Biophysics, Fluid phase, Mechanotransduction, Layer (object-oriented design), 030304 developmental biology |
| الوصف: | The endothelial glycocalyx layer (EGL) is a brush-like layer that lines the internal surfaces of blood vessels. It is thought to serve a number of physiological functions, including as a mechanotransducer of fluid loadings to the vessel wall. However, the fragility of the EGL makes it difficult to examine experimentally, and so there is much value in theoretical models that can help to explain the dynamical behaviour of the EGL. Most previous models have employed mixture theory to mechanically describe the layer, which treats the EGL as a isotropic linearly poroelastic layer. However, there is increasing experimental evidence to suggest that the EGL has a well-defined organisational structure that might not necessarily be well captured by such mixture theory descriptions. We therefore employ homogenisation theory to incorporate into the models some of the possible EGL microstructure suggested by the current biological literature. We explore how mechanotransduction varies under the different possible EGL microstructures, which potentially has important consequences to our understanding of how structural changes to the EGL might affect a vessel’s ability to respond to hemodynamical cues. We also find that, whereas mechanotransduction through the solid components of the EGL is dominated by the fluid tractions applied at the lumen–EGL interface, the component carried through its fluid phase is most sensitive to pressure gradients within the bulk EGL. This is relevant, since it is known that the underlying endothelial cells respond differently to these two different forms of mechanical loading. |
| تدمد: | 1469-7645 0022-1120 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::27d92e4d6618a39a359a99fc395ed570 https://doi.org/10.1017/jfm.2020.249 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........27d92e4d6618a39a359a99fc395ed570 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14697645 00221120 |
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