Synthesis and Antimycobacterial Activity of 5-(Hetarylmethylidene)-2,4,6-Pyrimidine- 2,4,6(1H,3H,5H )-Triones And 5-(2-Chloropropylidene)- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H )-Triones
| العنوان: | Synthesis and Antimycobacterial Activity of 5-(Hetarylmethylidene)-2,4,6-Pyrimidine- 2,4,6(1H,3H,5H )-Triones And 5-(2-Chloropropylidene)- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H )-Triones |
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| المؤلفون: | N. M. Gabitova, M. Yu. Yushin, A. K. Ayupova, A. V. Khrapova, A. G. Tyrkov, G. N. Genatullina, L. V. Saroyants |
| المصدر: | Pharmaceutical Chemistry Journal. 54:134-137 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pharmacology, Low toxicity, Pyrimidine, 010405 organic chemistry, Chemistry, medicine.drug_class, Pharmacology toxicology, Dapsone, Antimycobacterial, 01 natural sciences, Medicinal chemistry, Acute toxicity, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Drug Discovery, medicine, medicine.drug |
| الوصف: | Series of 5-(hetarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)- 2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones were synthesized and tested for antimycobacterial activity against M. lufu and acute toxicity. The 5-(hetarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones were shown to possess low toxicity and antimycobacterial activity of various strengths as compared to dapsone and could be considered promising compounds for further discovery of antimycobacterial drugs. |
| تدمد: | 1573-9031 0091-150X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::280bab4e6d40e7ed0d25d2427b0980db https://doi.org/10.1007/s11094-020-02169-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........280bab4e6d40e7ed0d25d2427b0980db |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15739031 0091150X |
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