التفاصيل البيبلوغرافية
| العنوان: |
Data from Cadherin-11 Increases Migration and Invasion of Prostate Cancer Cells and Enhances their Interaction with Osteoblasts |
| المؤلفون: |
Sue-Hwa Lin, Li-Yuan Yu-Lee, Christopher J. Logothetis, Fe-Lin Lin Wu, Angelica Ortiz, Soo Mi Kim, Xiangcang Ye, Yu-Chen Lee, Mehmet Asim Bilen, Khoi Chu, Cristina Lira, Chih-Fen Huang |
| بيانات النشر: |
American Association for Cancer Research (AACR), 2023. |
| سنة النشر: |
2023 |
| الوصف: |
Cell adhesion molecules have been implicated in the colonization of cancer cells to distant organs. Prostate cancer (PCa) has a propensity to metastasize to bone, and cadherin-11, which is an osteoblast cadherin aberrantly expressed in PCa cells derived from bone metastases, has been shown to play a role in the metastasis of PCa cells to bone. However, the mechanism by which cadherin-11 is involved in this process is not known. Here, we show that expression of cadherin-11 in cadherin-11–negative C4-2B4 cells increases their spreading and intercalation into an osteoblast layer and also stimulates C4-2B4 cell migration and invasiveness. The downregulation of cadherin-11 in cadherin-11–expressing metastatic PC3 cells decreases cell motility and invasiveness. Further, both the juxtamembrane (JMD) and β-catenin binding domains (CBS) in the cytoplasmic tail of cadherin-11 are required for cell migration and invasion, but not spreading. Gene array analyses showed that several invasion-related genes, including MMP-7 and MMP-15, are upregulated in cadherin-11–expressing, but not in cad11-ΔJMD–expressing or cad11-ΔCBS–expressing, C4-2B4 cells. These observations suggest that cadherin-11 not only provides a physical link between PCa cells and osteoblasts but also increases PCa cell motility and invasiveness that may facilitate the metastatic colonization of PCa cells in bone. Cancer Res; 70(11); 4580–9. ©2010 AACR. |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::2838c513120eebb47140f0c217f93fb5
https://doi.org/10.1158/0008-5472.c.6500594 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........2838c513120eebb47140f0c217f93fb5 |
| قاعدة البيانات: |
OpenAIRE |
