5-HT containing enteroendocrine cells characterised by morphologies, patterns of hormone co-expression, and relationships with nerve fibres in the mouse gastrointestinal tract
| العنوان: | 5-HT containing enteroendocrine cells characterised by morphologies, patterns of hormone co-expression, and relationships with nerve fibres in the mouse gastrointestinal tract |
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| المؤلفون: | John B. Furness, Ada Koo, Hirofumi Kuramoto, Linda J Fothergill |
| المصدر: | Histochemistry and Cell Biology. 155:623-636 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Histology, 030102 biochemistry & molecular biology, Stomach, Motility, Enteroendocrine cell, Cell Biology, Histidine decarboxylase, Cell biology, Oxyntomodulin, 03 medical and health sciences, Medical Laboratory Technology, chemistry.chemical_compound, Basal (phylogenetics), 030104 developmental biology, medicine.anatomical_structure, chemistry, medicine, Secretion, Molecular Biology, Antrum |
| الوصف: | 5-HT containing enteroendocrine cells (EEC), the most abundant type of EEC in the gut, regulate many functions including motility, secretion and inflammatory responses. We examined the morphologies of 5-HT cells from stomach to rectum, patterns of hormone co-expression in the stomach and colon, and the relationship of 5-HT cells with nerve fibres. We also reviewed some of the relevant literature. The morphologies of 5-HT cells were distinct, depending on their location in the gut. A noticeable feature of some 5-HT cells in the antrum and colon was their long basal processes, which resembled processes of neurons, whereas 5-HT cells in the small intestinal mucosa lacked basal processes. In the stomach, numerous 5-HT cells, including cells with basal processes, were identified as enterochromaffin-like cells by their expression of histidine decarboxylase. In the colon, we observed a small number of 5-HT cells that were in close contact with, but distinct from, oxyntomodulin (OXM) and PYY immunoreactive EEC. We did not find specific relationships between nerve fibres and the processes of colonic 5-HT cells. We conclude that five major features, i.e., gut region, morphology, hormone content, receptor repertoire and cell lineage, can be used to define 5-HT cells. |
| تدمد: | 1432-119X 0948-6143 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2877fd735475f09d706a5c41411dd1f5 https://doi.org/10.1007/s00418-021-01972-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........2877fd735475f09d706a5c41411dd1f5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1432119X 09486143 |
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