Highly Elastic and Tough Interpenetrating Polymer Network-Structured Hybrid Hydrogels for Cyclic Mechanical Loading-Enhanced Tissue Engineering
| العنوان: | Highly Elastic and Tough Interpenetrating Polymer Network-Structured Hybrid Hydrogels for Cyclic Mechanical Loading-Enhanced Tissue Engineering |
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| المؤلفون: | Oju Jeon, Hong Hyun Park, Jung Youn Shin, Eben Alsberg, Robyn Marks, Mitchell Hopkins, Tae-Hee Kim |
| المصدر: | Chemistry of Materials. 29:8425-8432 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Reaction conditions, Materials science, food.ingredient, Biocompatibility, General Chemical Engineering, technology, industry, and agriculture, Nanotechnology, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Biocompatible material, 01 natural sciences, Gelatin, 0104 chemical sciences, Gel strength, food, Tissue engineering, Self-healing hydrogels, Materials Chemistry, Interpenetrating polymer network, Composite material, 0210 nano-technology |
| الوصف: | Although hydrogels are extensively investigated as biomaterials due to their ability to mimic cellular microenvironments, they are often limited by their poor physical properties in response to mechanical loads, including weak gel strength, brittleness, and permanent deformation. Recently, interpenetrating polymer network (IPN) hydrogels have gained substantial attention for their use in investigating changes in encapsulated cell behaviors under mechanical stimulation. However, despite recent success in developing highly elastic IPN-structured hydrogels, it remains a great technical challenge to endow them with biocompatibility and biodegradability due to use of toxic chemicals, nonbiodegradable prepolymers, and harsh reaction conditions. In this study, we report on the synthesis and formation of highly elastic and tough IPN-structured hydrogels based on alginate and gelatin, which are biocompatible and biodegradable. Mechanical stimulation enhanced the proliferation and osteogenic differentiation of enca... |
| تدمد: | 1520-5002 0897-4756 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2968dcadc249cb274b756a1874a49847 https://doi.org/10.1021/acs.chemmater.7b02995 |
| رقم الأكسشن: | edsair.doi...........2968dcadc249cb274b756a1874a49847 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205002 08974756 |
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