Investigation of gene markers and pathways in macrophages responsible for the Th1/Th17 inflammatory condition of Periodontal infection that can be candidates in stem cell therapy of the disease
| العنوان: | Investigation of gene markers and pathways in macrophages responsible for the Th1/Th17 inflammatory condition of Periodontal infection that can be candidates in stem cell therapy of the disease |
|---|---|
| المؤلفون: | Chikoo Cherian, Jannet Vennila James |
| المصدر: | Bangladesh Journal of Medical Science. 19:594-597 |
| بيانات النشر: | Bangladesh Journals Online (JOL), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Periodontal infection, business.industry, Genetic marker, medicine.medical_treatment, Immunology, Medicine, General Medicine, Disease, Stem-cell therapy, Th1 th17, business |
| الوصف: | Periodontitis is defined as a chronic gum disease with characteristic inflammation attributed byTh1/Th17 showing excessive immune responses and Tregs dysregulation occurring in the macrophages. Several genes and associated pathways have been identified which influence this condition. By deploying bioinformatics approaches and tools, the authors of this paper validated the presence of the responsible genes and identified its pathways. The current study focuses on using these genes as molecular markers and inhibiting their pathways in addition to conditioning the conversion of Th17 cells into Treg cells by introducing stem cell therapy. This study specifically used Wharton jelly or Umbilical cord stem cells therapy in the control and treatment of Periodontitis. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.594-597 |
| تدمد: | 2076-0299 2223-4721 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2c45aff187e8afe8a72f74f777a10be0 https://doi.org/10.3329/bjms.v19i4.46611 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........2c45aff187e8afe8a72f74f777a10be0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20760299 22234721 |
|---|