Strategies for the successful implementation of plasma-based NSCLC genotyping in clinical practice
| العنوان: | Strategies for the successful implementation of plasma-based NSCLC genotyping in clinical practice |
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| المؤلفون: | Lynette M. Sholl, David R. Gandara, Christian D. Rolfo, Geoffrey R. Oxnard, Jhanelle E. Gray, Charu Aggarwal |
| المصدر: | Nature Reviews Clinical Oncology. 18:56-62 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, business.industry, Extramural, Clinical Practice, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Routine clinical practice, Clinical care, business, Genotyping |
| الوصف: | Upfront tumour genotyping is now considered an essential step in guiding treatment decision-making in the management of patients with advanced-stage non-small-cell lung cancer (NSCLC) in light of the ever-expanding toolbox of targeted therapies and immune-checkpoint inhibitors. However, genotyping of tumour biopsy samples is not feasible for all patients and, therefore, genomic analysis of circulating tumour DNA (ctDNA) has emerged as a compelling non-invasive option. Current guidelines universally recommend genotyping and support the use of ctDNA testing in certain settings, although they often omit the detail necessary for integrating these tests into clinical care on an individual basis. In this Perspective, we describe the rationale, promise and challenges associated with ctDNA-based NSCLC genotyping and suggest a framework for the implementation of these assays into routine clinical practice. We also offer considerations for the interpretation of ctDNA genotyping results, which, particularly when using next-generation sequencing panels, can be nuanced. Through the addition of this new approach to clinical practice, we propose that oncologists might finally be able to utilize effective genotyping in nearly all patients with advanced-stage NSCLC. |
| تدمد: | 1759-4782 1759-4774 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2ceb19e294f7cc3d21987c7a111ea523 https://doi.org/10.1038/s41571-020-0423-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........2ceb19e294f7cc3d21987c7a111ea523 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17594782 17594774 |
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