Differential Effects of Interleukin-Iα, Tumor Necrosis Factor-α, Indomethacin, Hydrocortisone, and Macrophage Co-Culture on the Proliferation of Human Fibroblasts and Peritoneal Mesothelial Cells
التفاصيل البيبلوغرافية
العنوان:
Differential Effects of Interleukin-Iα, Tumor Necrosis Factor-α, Indomethacin, Hydrocortisone, and Macrophage Co-Culture on the Proliferation of Human Fibroblasts and Peritoneal Mesothelial Cells
We sought to determine whether human fibroblasts and peritoneal mesothelial cells (PMC) are under comparable proliferative controls. Human PMC and human fibroblasts were obtained from primary culture of excised explants from infertile women. The proliferation of PMC, as determined by tritiated thymidine incorporation, was compared with that of fibroblasts in the presence of human peritoneal macrophages, interleukin-1α (IL-1), tumor necrosis factor-α (TNF), indomethacin, and hydrocortisone. Data were analyzed by one-way and multifactorial analyses of variance, with Bonferroni adjustments for multiple comparisons. Disparate proliferation was observed between fibroblasts and mesothelial celts with the additives studied. Proliferation of fibroblasts was inhibited (P
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