Diminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis
| العنوان: | Diminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis |
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| المؤلفون: | Alfredo L Sklar, Xi Ren, Lydia Chlpka, Mark Curtis, Brian A Coffman, Dean F Salisbury |
| المصدر: | Schizophrenia Bulletin. 49:679-687 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Psychiatry and Mental health |
| الوصف: | Background and Hypothesis There is growing appreciation for the contribution of sensory disruptions to disease morbidity in psychosis. The present study examined auditory cortex (AC) dynamic range: the scaling of neurophysiological responses to stimulus intensity, among individuals with a schizophrenia spectrum illness (FESz) and its relationship to clinical outcomes at disease onset. Study Design Magnetoencephalography (MEG) was recorded from 35 FESz and 40 healthy controls (HC) during binaural presentation of tones at three intensities (75 dB, 80 dB, and 85 dB). MRIs were obtained to enhance cortical localization of MEG sensor-level activity. All participants completed the MATRICS cognitive battery (MCCB) and Global Functioning: Role and Social scales (GFR/GFS). Patients were administered the Positive and Negative Syndrome Scale (PANSS). Study Results FESz exhibited reduced AC response relative to HC. Enhancement of AC activity to tones of increasing intensity was blunted in FESz relative to HC. Reduced dynamic range (85–75 dB AC response) was associated with lower GFS (r = .58) and GFR (r = .45) scores, worse MCCB performance (r = .45), and increased PANSS Negative symptom subscale scores (r = −.55) among FESz, relationships not observed with AC responses to individual tones. Conclusion Beyond an impaired AC response to pure tones, FESz exhibit reduced dynamic range relative to HC. This impairment was correlated with markers of disease morbidity including poorer community functioning as well as cognitive and negative symptoms. The relationship with impaired social functioning may reflect the role of AC dynamic range in decoding the emotional content of language and highlights its importance to future therapeutic sensory remediation protocols. |
| تدمد: | 1745-1701 0586-7614 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2db387061504a74fc4eea37f032e3989 https://doi.org/10.1093/schbul/sbac208 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........2db387061504a74fc4eea37f032e3989 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17451701 05867614 |
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