Defective Autophagy and Mitophagy in Alzheimer’s Disease: Mechanisms and Translational Implications
| العنوان: | Defective Autophagy and Mitophagy in Alzheimer’s Disease: Mechanisms and Translational Implications |
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| المؤلفون: | Jie Chen, Cheng-Long Xie, Feifei Feng, Ruiyu Han, Wen-Wen Wang, Hai-Jun He, Qianqian Ye, Yingying Gu |
| المصدر: | Molecular Neurobiology. 58:5289-5302 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Drug candidate, Autophagy, Disease mechanisms, Neuroscience (miscellaneous), Disease, Biology, medicine.disease, Cellular and Molecular Neuroscience, Multiple factors, Neurology, Mitophagy, medicine, Dementia, Neuroscience, Intracellular |
| الوصف: | The main histopathology of Alzheimer's disease (AD) is featured by the extracellular accumulation of amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles (NFT) in the brain, which is likely to result from co-pathogenic interactions among multiple factors, e.g., aging or genes. The link between defective autophagy/mitophagy and AD pathologies is still under investigation and not fully established. In this review, we consider how AD is associated with impaired autophagy and mitophagy, and how these impact pathological hallmarks as well as the potential mechanisms. This complicated interplay between autophagy or mitophagy and histopathology in AD suggests that targeting autophagy or mitophagy probably is a promising anti-AD drug candidate. Finally, we review the implications of some new insights for induction of autophagy or mitophagy as the new therapeutic way that targets processes upstream of both NFT and Aβ plaques, and hence stops the neurodegenerative course in AD. |
| تدمد: | 1559-1182 0893-7648 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2e06e49f1fc20058effc50d42d811050 https://doi.org/10.1007/s12035-021-02487-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........2e06e49f1fc20058effc50d42d811050 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15591182 08937648 |
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