Epigenome-wide meta-analysis of BMI in nine cohorts: examining the utility of epigenetic BMI in predicting metabolic health

التفاصيل البيبلوغرافية
العنوان: Epigenome-wide meta-analysis of BMI in nine cohorts: examining the utility of epigenetic BMI in predicting metabolic health
المؤلفون: Whitney L. Do, Dianjianyi Sun, Karlijn Meeks, Pierre-Antoine Dugue, Ellen Demerath, Weihua Guan, Shengxu Li, Wei Chen, Roger Milne, Abedowale Adeyemo, Charles Agyemang, Rami Nassir, JoAnn Manson, Aladdin H Shadyab, Lifang Hou, Steve Horvath, Themistocles L. Assimes, Parveen Bhatti, Kristina Jordahl, Andrea Baccarelli, Alicia Smith, Lisa R. Staimez, Aryeh Stein, Eric A. Whitsel, K.M. Venkat Narayan, Karen Conneely
بيانات النشر: Cold Spring Harbor Laboratory, 2022.
سنة النشر: 2022
الوصف: This study sought to examine the association between DNA methylation and body mass index (BMI) and the potential utility of these cytosine-phosphate-guanine (CpG) sites in predicting metabolic health. We pooled summary statistics from six trans-ethnic EWAS of BMI representing nine cohorts (n=17058), replicated these findings in the Women’s Health Initiative (WHI, n=4822) and developed an epigenetic prediction score of BMI. In the pooled EWAS, 1265 CpG sites were associated with BMI (p
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2edd1c67de30f76d0611b46614a97cc1
https://doi.org/10.1101/2022.07.26.498234
رقم الأكسشن: edsair.doi...........2edd1c67de30f76d0611b46614a97cc1
قاعدة البيانات: OpenAIRE