Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors
| العنوان: | Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors |
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| المؤلفون: | Ying Shen, San-Qi Zhang, Minhang Xin, Hao Zhang, Hui-Yan Wang |
| المصدر: | Journal of Chemical Research. 44:393-402 |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Phosphoinositide 3-kinase, biology, Biochemistry, Chemistry, biology.protein, Biological activity, General Chemistry |
| الوصف: | Twenty-five novel 2,4,6-trisubstituted triazines were synthesized and biologically evaluated. Most of the compounds synthesized showed good antiproliferative activity against HCT-116 and MCF-7. Compounds B18 and B19 showed the best antiproliferative activity. Further study showed B18 and B19 inhibited four phosphoinositide 3-kinase isoforms and mammalian target of rapamycin with good potency. These results demonstrate that 2,4,6-trisubstituted triazines are potentially useful phosphoinositide 3-kinase inhibitors for the development of new anticancer drugs. |
| تدمد: | 2047-6507 1747-5198 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2f10348cc7291823ab0804a733deb926 https://doi.org/10.1177/1747519820904844 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........2f10348cc7291823ab0804a733deb926 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20476507 17475198 |
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