Acute myeloid leukemia with an unusual histologic pattern mimicking metastatic carcinoma in bone marrow: a diagnostic pitfall
| العنوان: | Acute myeloid leukemia with an unusual histologic pattern mimicking metastatic carcinoma in bone marrow: a diagnostic pitfall |
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| المؤلفون: | Qin Huang, Mingyi Chen, Karl Gaal, Lawrence M. Weiss, Karen Chang, Young L. Kim |
| المصدر: | Journal of Hematopathology. 4:117-122 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pathology, Histology, Myeloid, Hematology, medicine.diagnostic_test, business.industry, CD33, Myeloid leukemia, medicine.disease, Pancytopenia, Pathology and Forensic Medicine, Metastatic carcinoma, medicine.anatomical_structure, hemic and lymphatic diseases, Internal medicine, Biopsy, Medicine, Bone marrow, business |
| الوصف: | We describe two cases of acute myeloid leukemia with an unusual histological pattern mimicking metastatic non-hematopoietic neoplasm, leading to diagnostic difficulties. Both patients presented with pancytopenia and absence of circulating blasts. Bone marrow aspirations were not successful. Bone marrow core biopsies contained neoplastic cells arranged in cohesive sheets or single file patterns with prominent myxoid stroma resembling metastatic carcinoma. The accompanying bone marrow touch imprints showed clusters of immature cells with monocytoid features. The cell lineage was further revealed by immunohistochemical analysis of bone marrow core biopsy sections. The neoplastic cells showed strong reactivity for myeloperoxidase, CD33, CD43, CD45, and CD68, indicating a myeloid cell origin with monocytic differentiation. One patient (age, 39 years) received standard chemotherapy for acute myeloid leukemia, which resulted in remission of bone marrow disease. The other patient (age, 85 years) died with multiple organ failure before treatment. Failure to recognize these unusual histological features of acute myeloid leukemia could result in misdiagnosis from bone marrow biopsy. |
| تدمد: | 1865-5785 1868-9256 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2ffd6792fc58acf9d3088802248aa8a3 https://doi.org/10.1007/s12308-011-0090-z |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........2ffd6792fc58acf9d3088802248aa8a3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18655785 18689256 |
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