Anti-diarrheal, anti-secretory, anti-spasmodic and antiulcer activities of Acacia modesta (Mimosaceae) aerial parts
| العنوان: | Anti-diarrheal, anti-secretory, anti-spasmodic and antiulcer activities of Acacia modesta (Mimosaceae) aerial parts |
|---|---|
| المؤلفون: | Arif-ullah Khan, Neelam Gul Qazi, Fawad Ali |
| المصدر: | Tropical Journal of Pharmaceutical Research. 16:2231 |
| بيانات النشر: | African Journals Online (AJOL), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Loperamide, Papaverine, Traditional medicine, business.industry, Alkaloid, Pharmaceutical Science, Pharmacology, In vitro, Jejunum, Atropine, Diarrhea, medicine.anatomical_structure, medicine, Pharmacology (medical), Antispasmodic, medicine.symptom, business, medicine.drug |
| الوصف: | Purpose: To explore the pharmacological basis for folkloric use of Acacia modesta for treating diarrhea and gastrointestinal spasm. Methods: Acacia modesta crude extract (Am.Cr) for antidiarrheal activity (100, 300 and 1000 mg/kg) was investigated in terms of reduction in diarrhea droppings in castor-oil induced diarrhea, while antisecretory activity (300 and 1000 mg/kg) was studied in castor-oil induced model in mice. Isolated rabbit jejunum tissues were employed for in vitro experiments. For antiulcer assay, ethanol-induced gastrointestinal ulcer rat model was used. Results: Am.Cr tested positive for alkaloid, tannins and flavonoids. It exhibited protective effect against castor oil-induced diarrhea and intestinal fluid accumulation in mice at 100 - 1000 mg/kg, similar to the standard drugs, loperamide and atropine respectively. In isolated tissue (rabbit jejunum), Am.Cr concentration-dependently (0.01 - 3.0 mg/mL) produced relaxation of K + (80 mM)-induced and spontaneous contractions at concentrations to papaverine. Am.Cr significantly inhibited ( p < 0.001) ethanol-induced gastric ulceration in rats. In acute toxicity testing Am.Cr did not produce any mortality up to 5 g/kg dose. Conclusion: These results show that Acacia modesta possesses anti-diarrheal, anti-secretory, antispasmodic and anti-ulcer activities, probably mediated through dual mechanisms, including Ca 2+ influx and PDE enzyme(s) inhibition. The presence of phytochemicals, such as flavonoids and tannins, suggest the validity of the acclaimed ethnomedicinal effects in hyperactive gut disorders. Keywords: Acacia modesta , Antidiarrheal, Antisecretory, Antispasmodic, Antiulcer |
| تدمد: | 1596-9827 1596-5996 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::30cf1f366b252e7a9082b9b81ce31b3a https://doi.org/10.4314/tjpr.v16i9.26 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........30cf1f366b252e7a9082b9b81ce31b3a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15969827 15965996 |
|---|