A New Polyketide-Derived Metabolite with PTP1B Inhibitory Activity from the Endophytic Fungus Pestalotiopsis neglecta
| العنوان: | A New Polyketide-Derived Metabolite with PTP1B Inhibitory Activity from the Endophytic Fungus Pestalotiopsis neglecta |
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| المؤلفون: | Xiao-Fang Li, Fei-Xiang Xie, Wenbin Gao, Li-Ping Han, Qing-Yun Ma, Jun Zhang, You-Xing Zhao, Du-Qiang Luo |
| المصدر: | Chemistry of Natural Compounds. 55:1056-1058 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Polyketide, chemistry.chemical_compound, chemistry, Metabolite, Plant Science, General Chemistry, Endophytic fungus, Inhibitory postsynaptic potential, IC50, General Biochemistry, Genetics and Molecular Biology, Pestalotiopsis neglecta, Microbiology |
| الوصف: | A new polyketide-derived metabolite, named neglectine A, was isolated from cultures of the endophytic fungus Pestalotiopsis neglecta. Its structure was elucidated by analysis of 1D and 2D spectroscopic data as well as MS. Neglectine A possessed a rare bis-tetrahydrofuran ring system and showed moderate activities against SHP1, CDC25B, and PTP1B, with IC50 value of 17.1 μg/mL, 24.0 μg/mL, and 6.7 μg/mL, respectively. It is important to note that neglectine A has exhibited significant selectivity between PTP1B and CDC25B, LAR, SHP1, and SHP2. This is the first time that neglectine A is reported to have significant PTP1B inhibitory action. |
| تدمد: | 1573-8388 0009-3130 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::315f81df81ddb39d0c9edf78481999d8 https://doi.org/10.1007/s10600-019-02892-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........315f81df81ddb39d0c9edf78481999d8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15738388 00093130 |
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