The Significance of Transcriptomic Signatures in the Multifocal Papillary Thyroid Carcinoma: Two mRNA Expression Patterns with Distinctive Clinical Behavior from The Cancer Genome Atlas (TCGA) Database
| العنوان: | The Significance of Transcriptomic Signatures in the Multifocal Papillary Thyroid Carcinoma: Two mRNA Expression Patterns with Distinctive Clinical Behavior from The Cancer Genome Atlas (TCGA) Database |
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| المؤلفون: | Lee Ju Hee, Lee Dong Jin, Bon Seok Koo, Kangyeaeun, Boyoung Hwang, Hyon-Seung Yi, Minho Shong |
| المصدر: | International Journal of Thyroidology. 13:1-12 |
| بيانات النشر: | Korean Thyroid Association, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, endocrine system diseases, business.industry, Mrna expression, Genomics, medicine.disease_cause, Transcriptome, Gene expression profiling, Thyroid carcinoma, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Germline mutation, 030220 oncology & carcinogenesis, Cancer genome, Cancer research, Medicine, business, Thyroid neoplasm |
| الوصف: | Background and Objectives: The association between multifocal papillary thyroid carcinoma (PTC) and tumor aggressiveness remains controversial. The aim of study is to evaluate molecular subtypes of multifocal PTCs using multiplatform genomic analysis. Materials and Methods: Statistical analysis and genomic analysis were performed for gene expression data and clinical data of multifocal PTCs in The Cancer Genome Atlas data. Clinicopathologic findings, recurrence-free survival (RFS), copy number alteration and somatic mutation status in patients in relation to molecular subtypes were analyzed. Results: Multiplatform genomic analysis revealed that multifocal PTCs (n=226) were divided into two distinct molecular subgroups. Participants in cluster 2 showed significantly increased risk of extrathyroidal extension, lymph node metastasis, and BRAFV600E mutation compared to patients in cluster 1. To exclude the effect of BRAF mutation and RAS mutation on tumor aggressiveness, we compared clinical parameters between two clusters in patients without BRAF or RAS mutation. Cluster 2 showed significantly higher risk of lymph node metastasis compared to cluster 1. Conclusion: Multifocal PTC has two distinct molecular subtypes with distinctive clinical behaviors. Our data suggested the clinical implications of the transcriptomic signature to predict clinical outcomes of multifocal PTC. |
| تدمد: | 2466-1899 2384-3799 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::322ea93e5990c702b0d6aa18f9181850 https://doi.org/10.11106/ijt.2020.13.1.1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........322ea93e5990c702b0d6aa18f9181850 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24661899 23843799 |
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