Behavioral interventions as a treatment for epilepsy
| العنوان: | Behavioral interventions as a treatment for epilepsy |
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| المؤلفون: | Michael Privitera, Alok Dwivedi, Rachel S. Wasson, Susannah Cornes, Sian Cotton, Richard B. Lipton, Sheryl R. Haut, Jeffrey R. Strawn |
| المصدر: | Neurology. 90:e963-e970 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, medicine.medical_treatment, Psychological intervention, Diaphragmatic breathing, medicine.disease, law.invention, Treatment and control groups, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Mood, Randomized controlled trial, law, medicine, Physical therapy, 030212 general & internal medicine, Neurology (clinical), Behavioral interventions, business, 030217 neurology & neurosurgery, Progressive muscle relaxation |
| الوصف: | ObjectiveTo evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy.MethodsAdults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment. Daily self-reported mood and stress ratings plus seizure counts were completed by participants using an electronic diary, and no medication adjustments were permitted. The primary outcome was percent reduction in seizure frequency per 28 days comparing baseline and treatment; secondary outcomes included stress reduction and stress–seizure interaction.ResultsIn the 66 participants in the intention-to-treat analysis, seizure frequency was reduced from baseline in both treatment groups (PMR: 29%, p < 0.05; focused attention: 25%, p < 0.05). PMR and focused attention did not differ in seizure reduction (p = 0.38), although PMR was associated with stress reduction relative to focused attention (p < 0.05). Daily stress was not a predictor of seizures.ConclusionsBoth PMR and the focused-attention groups showed reduced seizure frequency compared to baseline in participants with medication-resistant focal seizures, although the 2 treatments did not differ. PMR was more effective than focused attention in reducing self-reported stress.ClinicalTrials.gov identifierNCT01444183. |
| تدمد: | 1526-632X 0028-3878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::32d2aab74311ec09bd640744f2e8cf28 https://doi.org/10.1212/wnl.0000000000005109 |
| رقم الأكسشن: | edsair.doi...........32d2aab74311ec09bd640744f2e8cf28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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