A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis
| العنوان: | A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis |
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| المؤلفون: | Changchuin Mao, Philip N. Tsichlis, Philip W. Hinds, Marei Dose, Miriam Enos, Amit Deshpande, Daqin Mao, Guo-fu Hu, Miaofen G. Hu, Fotini Gounari, Zhuyan Guo, Rui Chang, Elisabeth A. Hinds |
| المصدر: | Cancer Research. 69:810-818 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Cancer Research, Kinase, Cellular differentiation, Notch signaling pathway, Biology, medicine.disease_cause, Thymocyte, Oncology, Immunology, Knockout mouse, Cancer research, medicine, biology.protein, Cyclin-dependent kinase 6, Carcinogenesis, Protein kinase B |
| الوصف: | Cyclin-dependent kinase 6 (CDK6) promotes cell cycle progression and is overexpressed in human lymphoid malignancies. To determine the role of CDK6 in development and tumorigenesis, we generated and analyzed knockout mice. Cdk6-deficient mice show pronounced thymic atrophy due to reduced proliferative fractions and concomitant transitional blocks in the double-negative stages. Using the OP9-DL1 system to deliver temporally controlled Notch receptor–dependent signaling, we show that CDK6 is required for Notch-dependent survival, proliferation, and differentiation. Furthermore, CDK6-deficient mice were resistant to lymphomagenesis induced by active Akt, a downstream target of Notch signaling. These results show a critical requirement for CDK6 in Notch/Akt-dependent T-cell development and tumorigenesis and strongly support CDK6 as a specific therapeutic target in human lymphoid malignancies. [Cancer Res 2009;69(3):810–8] |
| تدمد: | 1538-7445 0008-5472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::337e2fb05ef81f3a21971602b4e36be0 https://doi.org/10.1158/0008-5472.can-08-2473 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........337e2fb05ef81f3a21971602b4e36be0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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